Overview

  • Product name

    Nafamostat Mesylate, Protease inhibitor
  • Description

    Broad spectrum, potent protease inhibitor
  • Biological description

    Broad spectrum, potent protease inhibitor (Ki = 95.3 pM). Inhibits NF-κB activation and complement activation. Selective for human tryptase.
  • Purity

    > 97%
  • CAS Number

    82956-11-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (6-Carbamimidoylnaphthalen-2-yl)4-(diaminomethylideneamino)benzoate methanesulfonic acid
  • Molecular weight

    539.59
  • Molecular formula

    C19H17N5O2.2CH4O3S
  • PubChem identifier

    5311180
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CS(=O)(=O)O.CS(=O)(=O)O.C1=CC(=CC=C1C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(=N)N)N=C(N)N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Fujiwara Y  et al. Nafamostat mesilate can prevent adhesion, invasion and peritoneal dissemination of pancreatic cancer thorough nuclear factor kappa-B inhibition. J Hepatobiliary Pancreat Sci 18:731-9 (2011). Read more (PubMed: 21484229) »
  • Li Q  et al. The complement inhibitor FUT-175 suppresses T cell autoreactivity in experimental autoimmune encephalomyelitis. Am J Pathol 175:661-7 (2009). Read more (PubMed: 19608865) »
  • Mori S  et al. Nafamostat mesilate is an extremely potent inhibitor of human tryptase. J Pharmacol Sci 92:420-3 (2003). Read more (PubMed: 12939527) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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