Overview

Description

  • Nature

    Synthetic
  • Amino Acid Sequence

    Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab206124 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Blocking - Blocking peptide for Anti-NAK/TBK1 (phospho S172) antibody [EPR2867(2)] (ab109272)

    • Form

      Liquid
    • Additional notes

      This is the blocking peptide for ab109272

      - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
      - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
      - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
      - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
      - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at -20°C.

    General Info

    • Alternative names

      • EC 2.7.11.1
      • FLJ11330
      • FTDALS4
      • NAK
      • NF kappa B activating kinase
      • NF kB activating kinase
      • NF-kappa-B-activating kinase
      • Serine/threonine protein kinase TBK 1
      • Serine/threonine protein kinase TBK1
      • Serine/threonine-protein kinase TBK1
      • T2K
      • TANK binding kinase 1
      • TANK-binding kinase 1
      • TBK 1
      • Tbk1
      • TBK1_HUMAN
      see all
    • Function

      Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively.
    • Tissue specificity

      Ubiquitous with higher expression in testis.
    • Sequence similarities

      Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
      Contains 1 protein kinase domain.
    • Cellular localization

      Cytoplasm.
    • Information by UniProt

    References

    ab206124 has not yet been referenced specifically in any publications.

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