Key features and details
- Rabbit polyclonal to NALP12/NLRP12
- Suitable for: ICC/IF, WB, IHC-P
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-NALP12/NLRP12 antibody
DescriptionRabbit polyclonal to NALP12/NLRP12
Tested applicationsSuitable for: ICC/IF, WB, IHC-Pmore details
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide corresponding to Human NALP12/NLRP12 (N terminal).
Database link: NP_653288
- Human brain tissue lysate
This product was previously labelled as NALP12
Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferPreservative: 0.02% Sodium azide
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab105409 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use a concentration of 20 µg/ml.|
|WB||Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 120 kDa.|
|IHC-P||Use at an assay dependent concentration.|
FunctionMay mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
Tissue specificityDetected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
Involvement in diseaseDefects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2) [MIM:611762]. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold.
Sequence similaritiesBelongs to the NLRP family.
Contains 1 DAPIN domain.
Contains 8 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.
- Information by UniProt
- CLR19.3 antibody
- FCAS2 antibody
- Monarch 1 antibody
ab105409 has been referenced in 1 publication.
- Shen M & Meng L Peripheral blood miR-372 as a biomarker for ulcerative colitis via direct targeting of NLRP12. Exp Ther Med 18:1486-1492 (2019). PubMed: 31363381