Overview

  • Product name

    Anti-NALP12/NLRP12 antibody
  • Description

    Rabbit polyclonal to NALP12/NLRP12
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human NALP12/NLRP12 (N terminal).
    Database link: NP_653288

  • Positive control

    • Human brain tissue lysate
  • General notes

     This product was previously labelled as NALP12

     

Properties

Applications

Our Abpromise guarantee covers the use of ab105409 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 120 kDa.
IHC-P Use at an assay dependent concentration.

Target

  • Function

    May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
  • Tissue specificity

    Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
  • Involvement in disease

    Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2) [MIM:611762]. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold.
  • Sequence similarities

    Belongs to the NLRP family.
    Contains 1 DAPIN domain.
    Contains 8 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • CLR19.3 antibody
    • FCAS2 antibody
    • Monarch 1 antibody
    • Monarch-1 antibody
    • NACHT, leucine rich repeat and PYD containing 12 antibody
    • NACHT, LRR and PYD containing protein 12 antibody
    • NACHT, LRR and PYD domains-containing protein 12 antibody
    • NAL12_HUMAN antibody
    • NLR family, pyrin domain containing 12 antibody
    • NLRP12 antibody
    • Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12 antibody
    • OTTHUMP00000067227 antibody
    • PAN6 antibody
    • PYPAF7 antibody
    • PYRIN containing APAF1 like protein 7 antibody
    • PYRIN-containing APAF1-like protein 7 antibody
    • Regulated by nitric oxide antibody
    • RNO antibody
    • RNO2 antibody
    see all

Images

  • Immunofluorescence of NALP12/NLRP12 in Human brain tissue with ab105409 at 20 ug/mL.

  • Immunohistochemistry of Human brain tissue with ab105409 5 μg/mL.

  • Anti-NALP12/NLRP12 antibody (ab105409) at 1 µg/ml + Human brain tissue lysate at 15 µg

    Predicted band size: 120 kDa

References

This product has been referenced in:

  • Shen M & Meng L Peripheral blood miR-372 as a biomarker for ulcerative colitis via direct targeting of NLRP12. Exp Ther Med 18:1486-1492 (2019). Read more (PubMed: 31363381) »
See 1 Publication for this product

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