Overview

  • Product name

  • Description

    Rabbit polyclonal to NALP2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Monkey
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 506-736 of Human NALP2

  • Positive control

    • A431, H1299, HeLa or Molt 4 cell lysates
      Methanol fixed HeLa cells
  • General notes

    Keep as concentrated solution.

Properties

Applications

Our Abpromise guarantee covers the use of ab137569 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/5000 - 1/20000. Predicted molecular weight: 121 kDa.
ICC/IF 1/100 - 1/1000.

Target

  • Function

    Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
  • Tissue specificity

    Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain.
  • Sequence similarities

    Belongs to the NLRP family.
    Contains 1 DAPIN domain.
    Contains 8 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • Domain

    The DAPIN domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD.
    When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein folding.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • CLR19.9 antibody
    • FLJ20510 antibody
    • Leucine rich repeat and PYD containing protein 2 antibody
    • LRR and PYD domains-containing protein 2 antibody
    • NACHT antibody
    • NACHT domain antibody
    • NACHT leucine rich repeat and PYD containing 2 antibody
    • NACHT LRR and PYD domains containing protein 2 antibody
    • NALP2 antibody
    • NALP2_HUMAN antibody
    • NBS1 antibody
    • NLR family pyrin domain containing 2 antibody
    • NLRP2 antibody
    • Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 2 antibody
    • Nucleotide-binding site protein 1 antibody
    • PAN1 antibody
    • PYPAF2 antibody
    • PYRIN containing APAF1 like protein2 antibody
    • PYRIN domain and NACHT domain-containing protein 1 antibody
    • PYRIN-containing APAF1-like protein 2 antibody
    see all

Images

  • Anti-NALP2 antibody (ab137569) at 1/10000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size: 121 kDa



    7.5% SDS PAGE
  • Immunofluorescence analysis of methanol fixed HeLa cells, labelling NALP2 with ab137569 at 1/200 dilution (left), costained with Hoechst 33342 (right).

References

ab137569 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab137569.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up