Namoline, lysine-specific demethylase 1 inhibitor (ab144666)

Overview

  • Product name

    Namoline, lysine-specific demethylase 1 inhibitor
  • Description

    Selective, reversible lysine-specific demethylase 1 inhibitor
  • Alternative names

    • Namolin
  • Biological description

    Selective, reversible lysine-specific demethylase 1 (LSD1) inhibitor (IC50 = 51 μM). Silences androgen receptor-regulated gene expression. Shows antiproliferative effects in vivo.

  • Purity

    > 99%
  • CAS Number

    342795-11-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-Chloro-6-nitro-2-(trifluoromethyl)-4H-1-benzopyran-4-one
  • Molecular weight

    293.59
  • Molecular formula

    C10H3ClF3NO4
  • PubChem identifier

    715694
  • Storage instructions

    Store at -20°C (desiccating conditions).
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 12 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    [O-][N+](=O)c1ccc2OC(=C(Cl)C(=O)c2c1)C(F)(F)F
  • Source

    Synthetic

References

This product has been referenced in:

  • Willmann D  et al. Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor. Int J Cancer 131:2704-9 (2012). Read more (PubMed: 22447389) »

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