Overview

  • Product name

    Naphthofluorescein, Furin inhibitor
  • Description

    Cell-permeable furin inhibitor. pH-sensitive, selective fluorescent superoxide and H2O2 indicator
  • Biological description

    Cell-permeable furin inhibitor (IC50 = 12 μM). pH-sensitive, selective fluorescent superoxide and H2O2 indicator. Inhibits cancer cell invasion.
  • Purity

    > 95%
  • CAS Number

    61419-02-1
  • Chemical structure

    Chemical Structure

Properties

  • Excitation

    594nm
  • Emission

    594nm
  • Chemical name

    3,11-Dihydroxy-spiro[dibenzo[c,h]xanthene-7,1'-phthalan]-3'-one
  • Molecular weight

    432.42
  • Molecular formula

    C28H16O5
  • PubChem identifier

    3124834
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C2C(=C1)C(=O)OC23C4=C(C5=C(C=C4)C=C(C=C5)O)OC6=C3C=CC7=C6C=CC(=C7)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Gao W  et al. Functional roles of superoxide and hydrogen peroxide generated by mitochondrial DNA mutation in regulating tumorigenicity of HepG2 cells. Cell Biochem Funct 29:400-7 (2011). Read more (PubMed: 21590695) »
  • Albers AE  et al. A red-emitting naphthofluorescein-based fluorescent probe for selective detection of hydrogen peroxide in living cells. Bioorg Med Chem Lett 18:5948-50 (2008). Read more (PubMed: 18762422) »
  • Xu K  et al. A phosphinate-based red fluorescent probe for imaging the superoxide radical anion generated by RAW264.7 macrophages. Chembiochem 8:453-8 (2007). Read more (PubMed: 17238211) »

Customer reviews and Q&As

Answer

The only product we have is BCECF-AM Acetoxymethyl ester of BCECF intracellular ratiometric pH indicator, https://www.abcam.com/bcecf-am-ab143463.html.
The wavelengths given are however different than your requirements; therefore, please have a look at the datasheet and check if it matches your needs.

Read More

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

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