Key features and details
- Rho/Rho kinase/LIM kinase/cofilin signaling pathway activator
- CAS Number: 29477-83-6
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameNarciclasine, Rho/LIM kinase/cofilin signaling pathway activator
DescriptionRho/Rho kinase/LIM kinase/cofilin signaling pathway activator
- BRN 1087400
- NSC 266535
Plant growth regulator originally isolated from Narcissus bulbs. Exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC50 = 47 nM). Activity decreases rate of cell division and increases mitosis duration in vitro. Also modulates the Rho/ROCK/LIM kinase/cofilin pathway; stimulates RhoA activation and induces actin polymerization.
Storage instructionsShipped at 4°C. Store at -20°C. Store under desiccating conditions.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab218110 has not yet been referenced specifically in any publications.