Overview

  • Product name

    Nargenicin A1, Antibiotic agent
  • Description

    Broad spectrum antibiotic agent. Potential anti-inflammatory agent.
  • Biological description

    Broad spectrum antibiotic agent. Potential anti-inflammatory agent. Active against Gram-positive bacteria, particularly Staphylococcus and Clostridia. Attenuates LPS-induced nitric oxide production in microglia. Suppresses IL-1β, TNF-α and iNOS production.
  • Purity

    > 98%
  • CAS Number

    70695-02-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3S,4R,5R,6R,7S,8R,11S,13S,16S,17R,18E)-6-Hydroxy-16-[(1R)-1-hydroxyethyl]-13-methoxy-5,17,19-trimethyl-14-oxo-2,15-dioxatetracyclo[9.8.0.01,7.03,8]nonadeca-9,18-dien-4-yl-1H-pyrrole-2-carboxylate
  • Molecular weight

    515.60
  • Molecular formula

    C28H37NO8
  • PubChem identifier

    6326334
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@@H]1/C=C(/[C@]23[C@@H](C[C@@H](C(=O)O[C@@H]1[C@@H](C)O)OC)C=C[C@@H]4[C@H]2[C@@H]([C@H]([C@H]([C@@H]4O3)OC(=O)C5=CC=CN5)C)O)\C
  • Source

    Actinomyces sp.

  • Research areas

References

This product has been referenced in:

  • Koju D  et al. Effect of different biosynthetic precursors on the production of nargenicin A1 from metabolically engineered Nocardia sp. CS682. J Microbiol Biotechnol 22:1127-32 (2012). Read more (PubMed: 22713990) »
  • Yoo JC  et al. Nargenicin attenuates lipopolysaccharide-induced inflammatory responses in BV-2 cells. Neuroreport 20:1007-12 (2009). Read more (PubMed: 19474767) »
  • Ikeda Y  et al. A new destomycin-family antibiotic produced by Saccharopolyspora hirsuta. J Antibiot (Tokyo) 38:436-8 (1985). Read more (PubMed: 4008336) »

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