NASPM trihydrochloride, Ca2+-permeable AMPA receptor antagoinst (ab146810)

Overview

  • Product name

    NASPM trihydrochloride, Ca2+-permeable AMPA receptor antagoinst
  • Description

    Selective, Ca2+-permeable AMPA receptor antagoinst
  • Biological description

    Selective, Ca2+-permeable AMPA receptor antagonist. Blocks GluR2 subunit lacking AMPA channels. Shows neuroprotective effects.
  • CAS Number

    1049731-36-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[3-[4-(3-Aminopropylamino)butylamino]propyl]-2-naphthalen-1-ylacetamide trihydrochloride
  • Molecular weight

    479.31
  • Molecular formula

    C22H34N4O.3HCl
  • PubChem identifier

    16219727
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C2C(=C1)C=CC=C2CC(=O)NCCCNCCCCNCCCN.Cl.Cl.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Dong LD  et al. GluA2 trafficking is involved in apoptosis of retinal ganglion cells induced by activation of EphB/EphrinB reverse signaling in a rat chronic ocular hypertension model. J Neurosci 35:5409-21 (2015). Read more (PubMed: 25834064) »
  • Bender C  et al. Involvement of AMPA/kainate-excitotoxicity in MK801-induced neuronal death in the retrosplenial cortex. Neuroscience 169:720-32 (2010). Read more (PubMed: 20457221) »
  • Koike M  et al. Blocking effect of 1-naphthyl acetyl spermine on Ca(2+)-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res 29:27-36 (1997). Read more (PubMed: 9293490) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab146810.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up