Natamycin (Pimaricin), Protein synthesis inhibitor (ab142694)

Overview

  • Product name

    Natamycin (Pimaricin), Protein synthesis inhibitor
  • Description

    Protein synthesis inhibitor. Shows antifungal properties.
  • Biological description

    Protein synthesis inhibitor. Binds to the ribosomal 50S subunit. Shows antifungal properties.
  • Purity

    > 98%
  • CAS Number

    7681-93-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-[(3-Amino-3,6-dideoxy-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
  • Molecular weight

    665.73
  • Molecular formula

    C33H47NO13
  • PubChem identifier

    5281099
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC3C(O3)C=CC(=O)O1)O)O)O)C(=O)O)OC4C(C(C(C(O4)C)O)N)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Bhatta RS  et al. Bioanalytical method development and validation of natamycin in rabbit tears and its application to ocular pharmacokinetic studies. J Pharm Biomed Anal 54:1096-100 (2011). Read more (PubMed: 21168297) »
  • Saleem M  et al. Natamycin treatment of experimental Candida albicans induced keratomycosis in rabbits. West Indian Med J 56:526-9 (2007). Read more (PubMed: 18646497) »
  • Behrens-Baumann W & Klinge B [Natamycin (pimaricin) in the treatment of experimental keratomycosis]. Fortschr Ophthalmol 87:237-40 (1990). Read more (PubMed: 2376371) »

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