Native Carcino Embryonic Antigen CEA protein (ab742)
Key features and details
- Expression system: Native
- Purity: > 95% >95% by SDS-PAGE
- Suitable for: ELISA
Description
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Product name
Native Carcino Embryonic Antigen CEA protein
See all CEACAM5 proteins and peptides -
Purity
>95% by SDS-PAGE . -
Expression system
Native -
Protein length
Full length protein -
Animal free
No -
Nature
Native
Associated products
Specifications
Our Abpromise guarantee covers the use of ab742 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
ELISA
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Form
Liquid -
Additional notes
Blood samples from tissue donors were tested and found negative for HBsAg, HIV-1 and HIV-2 antibodies, HCV.SDS-PAGE denaturating : multiple protein bands 150 – 210 kDa
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
pH: 7.40
Preservative: 0.09% Sodium azide
Constituent: 2% Methyl mannoside
0.1 M PBS
General Info
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Alternative names
- Carcinoembryonic antigen
- Carcinoembryonic antigen-related cell adhesion molecule 5
- CD66e
see all -
Function
Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. -
Tissue specificity
Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. -
Sequence similarities
Belongs to the immunoglobulin superfamily. CEA family.
Contains 7 Ig-like (immunoglobulin-like) domains. -
Post-translational
modificationsComplex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate. -
Cellular localization
Cell membrane. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (5)
ab742 has been referenced in 5 publications.
- Yen YK et al. A Graphene-PEDOT:PSS Modified Paper-Based Aptasensor for Electrochemical Impedance Spectroscopy Detection of Tumor Marker. Sensors (Basel) 20:N/A (2020). PubMed: 32131502
- Liu J et al. Integrating Metal-Enhanced Fluorescence and Surface Acoustic Waves for Sensitive and Rapid Quantification of Cancer Biomarkers from Real Matrices. ACS Sens 3:222-229 (2018). PubMed: 29284267
- Sato M et al. Development and validation of scFv-conjugated affinity silk protein for specific detection of carcinoembryonic antigen. Sci Rep 7:16077 (2017). PubMed: 29167497
- Oberst MD et al. CEA/CD3 bispecific antibody MEDI-565/AMG 211 activation of T cells and subsequent killing of human tumors is independent of mutations commonly found in colorectal adenocarcinomas. MAbs 6:1571-84 (2014). PubMed: 25484061
- Li Y et al. Carcinoembryonic antigen interacts with TGF-{beta} receptor and inhibits TGF-{beta} signaling in colorectal cancers. Cancer Res 70:8159-68 (2010). PubMed: 20889724