Overview

  • Product name

    Native Clostridium difficile Toxoid B protein
  • Protein length

    Full length protein

Description

  • Nature

    Native
  • Source

    Native
  • Amino Acid Sequence
    • Molecular weight

      270 kDa

Specifications

Our Abpromise guarantee covers the use of ab124002 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    ELISA

  • Purity

    > 95 % SDS-PAGE.

  • Form

    Lyophilised
  • Additional notes

    Inactivation: Inactivated using formaldehyde. No cell rounding in the sensitive verocytotoxicity assay at 2µg/ml compared to active toxin lethal dose of 4pg/ml.
    Antigenicity: Maintained to be no less than 90% of original toxin strength as measured by direct ELISA.

    This protein is derived from a pathogenic organism, and may be involved in a disease process, consequently exposure may have adverse health effects.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C. Avoid freeze / thaw cycle. Reconstitute for long term storage.

    Constituents: 1.19% HEPES, 5% Sucrose, 0.88% Sodium chloride

  • Reconstitution
    Reconstitute in 250µl sterile distilled water.

General Info

  • Relevance

    Clostridium difficile, or C. difficile, a gram positive anaerobic bacterium, is the major causative agent of colitis and diarrhoea that can occur following antibiotic intake. C. difficile infection is one of the most common hospital acquired infections. When C. difficile colonize the gut, they release two potent toxins, toxin A and toxin B, which bind to certain receptors in the lining of the colon and ultimately cause diarrhoea and inflammation of the large intestine.

Images

  • SDS-PAGE showing ab124002 at 270kDa.

References

ab124002 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab124002.
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