Associated products


Our Abpromise guarantee covers the use of ab7531 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot



  • Form

  • Additional notes

    This product reacts with anti-Collagen Type VI. Reaction with anti-Collagen I, II, III, IV or V is negligible (typically less than 1% cross reactivity was detected by ELISA).

    This product is not recommended for use under denaturing conditions in WB, IP, and ELISA. We would suggest testing it under native conditions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 4.50
    Constituent: 0.82% Sodium acetate

General Info

  • Alternative names

    • Alpha 1 (VI) chain (61 AA)
    • CO6A1_HUMAN
    • COL6A1
    • COL6A2
    • COL6A3
    • collagen 6
    • Collagen alpha 2(VI) chain
    • Collagen alpha 3(VI) chain
    • Collagen alpha-1(VI) chain
    • collagen six
    • Collagen type VI alpha 1
    • Collagen type VI alpha 2
    • Collagen type VI alpha 3
    • Collagen VI alpha 1 polypeptide
    • Collagen VI alpha 2 polypeptide
    • Collagen VI alpha 3 polypeptide
    • CollagenVI
    • Human mRNA for collagen VI alpha 2 C terminal globular domain
    • OPLL
    • PP3610
    see all
  • Function

    Collagen VI acts as a cell-binding protein.
  • Involvement in disease

    Defects in COL6A1 are a cause of Bethlem myopathy (BM) [MIM:158810]. BM is a rare autosomal dominant proximal myopathy characterized by early childhood onset (complete penetrance by the age of 5) and joint contractures most frequently affecting the elbows and ankles.
    Defects in COL6A1 are a cause of Ullrich congenital muscular dystrophy (UCMD) [MIM:254090]; also known as Ullrich scleroatonic muscular dystrophy. UCMD is an autosomal recessive congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy.
  • Sequence similarities

    Belongs to the type VI collagen family.
    Contains 3 VWFA domains.
  • Post-translational

    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • Cellular localization

    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt


ab7531 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A


Thank you for contacting Abcam regarding our Collagen VI proteins.

I have confirmed with the laboratory that both proteins on our catalog have been pepsin-treated.

I hope this information is helpful and I apologize for any inconvenience this may cause. Please do not hesitate to contact us if you have any additional questions or concerns.

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Thank you for your recent technical enquiry. Because these proteins exist as chains in polymeric form, a precise MW is difficult to obtain. However, the average MW for these products ranges between 80kD and 120kD. I hope this information is helpful to you.

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