Product nameNative cow Factor X protein
See all Factor X proteins and peptides
Protein lengthFull length protein
Amino Acid Sequence
Molecular weight55 kDa
Additional sequence informationab187244 is prepared by activating purified Factor X with the Factor X activator isolated from Russell’s viper venom. Cleavage occurs at the Arg51-Ile52 bond and releases an activation peptide.
Our Abpromise guarantee covers the use of ab187244 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Activity 1921 U/mg
Extintion Coefficient 1.24
Measured in a Factor Xa clotting assay and/or chromogenic substrate assay.
Purity> 95 % SDS-PAGE.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C long term.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- Activated factor Xa heavy chain
- Coagulation factor X
FunctionFactor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
Tissue specificityPlasma; synthesized in the liver.
Involvement in diseaseDefects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.
Sequence similaritiesBelongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain.
modificationsThe vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
N- and O-glycosylated.
The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
- Information by UniProt
ab187244 has not yet been referenced specifically in any publications.