Product nameNative cow Factor Xa protein
See all Factor Xa proteins and peptides
Protein lengthFull length protein
Amino Acid Sequence
Additional sequence informationSource of the protein = Factor Xa is prepared by activating purified factor X with the factor X activator isolated from Russell's viper venom.
Our Abpromise guarantee covers the use of ab62231 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activitySpecific activity is ~1000 units/mg.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
Constituent: 50% Glycerol
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- Activated factor Xa heavy chain
- Coagulation factor X
FunctionFactor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
Tissue specificityPlasma; synthesized in the liver.
Sequence similaritiesBelongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain.
modificationsThe vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
N- and O-glycosylated.
The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
- Information by UniProt
ab62231 has not yet been referenced specifically in any publications.