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    native-cow-protein-c-ab81581.pdf

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Cardiovascular Blood Fibrinolysis / Thrombolysis
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Native cow Protein C (ab81581)

  • Datasheet
  • SDS
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SDS-PAGE - Native cow Protein C (ab81581)

    Key features and details

    • Expression system: Native
    • Purity: > 95% SDS-PAGE
    • Active: Yes
    • Suitable for: SDS-PAGE

    Description

    • Product name

      Native cow Protein C
      See all Protein C proteins and peptides
    • Biological activity

      <1% APC activity. Assay is performed to determine percent contaminating APC activity. APC activity is based on a APC standard curve. Chromagenic assay uses Spectrozyme-TH as substrate.

    • Purity

      > 95 % SDS-PAGE.

    • Expression system

      Native
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Native
      • Species

        Cow

    Specifications

    Our Abpromise guarantee covers the use of ab81581 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 7.40
      Constituents: 0.476% HEPES, 0.87% Sodium chloride

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    General Info

    • Alternative names

      • Activation peptide
      • Anticoagulant protein C
      • APC
      • Autoprothrombin IIA
      • Blood coagulation factor XIV
      • EC 3.4.21.69
      • PC
      • proC
      • PROC_HUMAN
      • PROC1
      • Protein C (inactivator of coagulation factors Va and VIIIa)
      • THPH3
      • THPH4
      • Vitamin K dependent protein C
      see all
    • Function

      Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).
    • Tissue specificity

      Plasma; synthesized in the liver.
    • Involvement in disease

      Thrombophilia due to protein C deficiency, autosomal dominant
      Thrombophilia due to protein C deficiency, autosomal recessive
    • Sequence similarities

      Belongs to the peptidase S1 family.
      Contains 2 EGF-like domains.
      Contains 1 Gla (gamma-carboxy-glutamate) domain.
      Contains 1 peptidase S1 domain.
    • Post-translational
      modifications

      The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.
      N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.
      The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
      May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.
    • Cellular localization

      Secreted. Golgi apparatus. Endoplasmic reticulum.
    • Target information above from: UniProt accession P04070 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Native cow Protein C (ab81581)
      SDS-PAGE - Native cow Protein C (ab81581)
      Novex 4-12% Bis-Tris
      1 µg per lane
      MOPS

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (1)

    Publishing research using ab81581? Please let us know so that we can cite the reference in this datasheet.

    ab81581 has been referenced in 1 publication.

    • Xiang T  et al. Vasculogenic mimicry formation in EBV-associated epithelial malignancies. Nat Commun 9:5009 (2018). PubMed: 30479336

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