Description

Specifications

Our Abpromise guarantee covers the use of ab134553 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

  • Form

    Lyophilised
  • Additional notes

    ab134553 contains large proteoglycans consisting of core proteins with attached glycosaminoglycans. Major components of the mixture are aggrecan and versican, which are hyaluronic acid-binding proteoglycans. Both contain hyaluronic acid binding regions, Ig-like domains, EGF like domains and lectin-like domains. As macromolecular polyanions they expand and hydrate the ECM in cartilage, intervertebral discs, dermis, blood vessel walls and brain tissue. Aggrecan and versican are degraded by proteases of the ADAMTS family. Aggrecan is cleaved by ADAMTS 1, 4, 5, 8, 9 and 15. Versican is hydrolyzed by ADAMTS 1, 4 and 9.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Store at +4°C.

General Info

  • Alternative names

    • Aggrecan
    • Versican

References

ab134553 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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