Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab90921 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Additional notes

    Protein Determination: Extinction Coefficient (E) 0.1% at 280nm, 1cm pathway = 0.703. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    pH: 6.40
    Constituents: 0.242% Tris, 1.16% Sodium chloride

General Info

  • Alternative names

    • A2AP
    • A2AP_HUMAN
    • AAP
    • Alpha 2 antiplasmin
    • Alpha 2 antiplasmin pigment epithelium derived factor
    • Alpha 2 AP
    • ALPHA 2 PI
    • Alpha 2 plasmin inhibitor
    • Alpha 2 plasmin inhibitor deficiency
    • Alpha-2-antiplasmin
    • Alpha-2-AP
    • Alpha-2-PI
    • Alpha-2-plasmin inhibitor
    • Antiplasmin deficiency
    • API
    • Plasmin inhibitor deficiency
    • PLI
    • Serine (or cysteine) peptidase inhibitor, clade F, member 2
    • Serine (Or cysteine) peptidase inhibitor, clade F, member 2, isoform CRA_c
    • Serine (or cysteine) proteinase inhibitor, clade F (alpha 2 antiplasmin pigment epithelium derived factor) member 2
    • Serine (Or cysteine) proteinase inhibitor, clade F, member 2
    • Serine or cysteine peptidase inhibitor clade F member 2
    • Serpin F2
    • Serpin peptidase inhibitor clade F
    • Serpin peptidase inhibitor, clade F (alpha 2 antiplasmin pigment epithelium derived factor) member 2
    • SERPINF2
    see all
  • Function

    Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.
  • Tissue specificity

    Expressed by the liver and secreted in plasma.
  • Involvement in disease

    Defects in SERPINF2 are the cause of alpha-2-plasmin inhibitor deficiency (APLID) [MIM:262850]. APLID is an autosomal recessive disorder resulting in severe hemorrhagic diathesis.
  • Sequence similarities

    Belongs to the serpin family.
  • Cellular localization

    Secreted.
  • Information by UniProt

Images

References

This product has been referenced in:

  • Zhao XJ  et al. Tissue plasminogen activator mediates deleterious complement cascade activation in stroke. PLoS One 12:e0180822 (2017). Mouse . Read more (PubMed: 28700732) »
See 1 Publication for this product

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