Description

Specifications

Our Abpromise guarantee covers the use of ab90925 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Additional notes

    Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

     This product was previously labelled as Apolipoprotein CII

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    pH: 7.40
    Constituent: 0.079% Ammonium bicarbonate

  • Reconstitution
    After initial centrifugation, we suggest the addition of the lyophilization buffer (10 mM ammonium bicarbonate, pH 7.4) to the original volume, followed by gentle swirling and/or vortexing to ensure adequate homogenization. If further dilution is required, please use the lyophilization buffer.

General Info

  • Alternative names

    • APC 2
    • APC2
    • Apo CII
    • Apo-CII
    • APOC 2
    • ApoC II
    • ApoC-II
    • APOC2
    • APOC2 protein
    • APOC2_HUMAN
    • ApoCII
    • Apolipoprotein C II
    • Apolipoprotein C II precursor
    • Apolipoprotein C2
    • ApolipoproteinCII
    • MGC75082
    • ProapoC-II
    • Proapolipoprotein C-II
    see all
  • Function

    Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.
  • Tissue specificity

    Liver and intestine.
  • Involvement in disease

    Hyperlipoproteinemia 1B
  • Sequence similarities

    Belongs to the apolipoprotein C2 family.
  • Post-translational
    modifications

    Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
    Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.
  • Cellular localization

    Secreted.
  • Information by UniProt

Images

  • SDS-PAGE analysis of ab90925 on an 18% Tris-Glycine Gel

    Lane 1: Apolipoprotein CII/ApoC-II - 10 μg (Reduced/heated)

    Lane 2: Apolipoprotein CII/ApoC-II - 15 μg (Reduced/heated)

    Lane 3: Molecular weight markers

    Lane 4: Apolipoprotein CII/ApoC-II - 10 μg (Non-reduced/no heat)

    Lane 5: Apolipoprotein CII/ApoC-II - 20 μg (Non-reduced/no heat)

References

ab90925 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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