Overview

  • Product name

    Native human Beta Thrombin protein
  • Protein length

    Full length protein

Description

  • Nature

    Native
  • Source

    Native
  • Amino Acid Sequence
    • Species

      Human
    • Amino acids

      328 to 622

Specifications

Our Abpromise guarantee covers the use of ab81591 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    <5% Thrombin activity. Specific activity is determined by Fibrinogen clotting assay relative to NIH standard thrombin. 1 NIH Unit = 1.15 IS Units
  • Applications

    Functional Studies

    SDS-PAGE

  • Purity

    > 95 % SDS-PAGE.

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 6.50
    Constituents: 0.164% Sodium phosphate, 1.74% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • Activation peptide fragment 1
    • Activation peptide fragment 2
    • Coagulation factor II
    • coagulation factor II (thrombin)
    • Prothrombin
    • prothrombin B chain
    • Thrombin heavy chain
    • Thrombin light chain
    see all
  • Relevance

    Thrombin is an active enzyme in the earliest steps of the blood clot formation, generated from its circulating inactive precursor prothrombin. Thrombin is a glycoprotein formed by two peptides chains of 36 and 259 amino acids linked by disulfure bonds. Three important sites have been identified on the surface of the enzyme: The catalytic site that confers to the molecule its serine protease activity, the exosite one responsible for the binding of the substrate (fibrinogen or thrombin receptor) and the exosite two responsible for the binding of antithrombin III and inactivation of thrombin. Beta Thrombin is a proteolyzed form of Alpha Thrombin.
  • Cellular localization

    Secreted, extracellular space.

References

ab81591 has not yet been referenced specifically in any publications.

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