Name: Native Human Collagen V protein
SKU: ab7537

Product name

Native Human Collagen V protein
See all Collagen V proteins and peptides
Protein length

Full length protein

Nature

Native
Source

Native
Amino Acid Sequence
- Accession
  
  P20908
- Species
  
  Human
- Molecular weight
  
  184 kDa
- Additional sequence information
  
  Prepared from Human Placenta and is chromatographically and immunologically pure.

Related Products
- Anti-Collagen V antibody (ab7046)

Our Abpromise guarantee covers the use of ab7537 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Biological activity

Collagen taken from human species.
Applications

Western blot

Immunoprecipitation

ELISA
Form

Liquid
Additional notes

This product is free from other collagens, human serum proteins and non-collagen extracellular matrix proteins. This product reacts with anti-Collagen Type V. Reaction with anti-Collagen I, II, III, IV or VI is negligible (typically less than 1% cross reactivity was detected by ELISA).
Collagen taken from human species.
Denaturing and reducing conditions will greatly diminish reactivity and selectivity of this protein.
Concentration information loading...

Stability and Storage

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

Preservative: 0.01% Sodium azide
Constituent: 0.06% Acetic acid

Alternative names
- AB collagen
- Alpha 1 type V collagen
- Alpha 2 type V collagen
- CO5A1_HUMAN
- COL5A1
- Col5A2
- COL5A2 protein
- Col5A3
- Collagen alpha 1(V) chain
- Collagen alpha 2 (V) chain precursor
- Collagen alpha 2(V) chain
- Collagen alpha 3(V) chain
- Collagen alpha-1(V) chain
- Collagen fetal membrane A polypeptide
- Collagen type V alpha 1
- Collagen type V alpha 2
- Collagen type V alpha 3
- Collagen V alpha 2 polypeptide
- CollagenV
- MGC105115
- OTTHUMP00000064637
- Pro alpha 1 type V collagen
- Pro alpha 3(V) collagen
- Procollagen alpha 2(V)
- Type V preprocollagen alpha 2 chain
see all
Function

Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.
Involvement in disease

Ehlers-Danlos syndrome 1
Ehlers-Danlos syndrome 2
Sequence similarities

Belongs to the fibrillar collagen family.
Contains 1 fibrillar collagen NC1 domain.
Contains 1 laminin G-like domain.
Domain

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
Post-translational
modifications

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Sulfated on 40% of tyrosines.
Cellular localization

Secreted > extracellular space > extracellular matrix.
Target information above from: UniProt accession P20908 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

Datasheet

ab7537 has not yet been referenced specifically in any publications.

Publishing research using ab7537? Please let us know so that we can cite the reference in this datasheet.

Location selector

Your location is currently set to:

Custom solutions & partnerships

Native Human Collagen V protein (ab7537)

Overview

Description

Associated products

Specifications

Preparation and Storage

General Info

Datasheets and documents

References

Customer reviews and Q&As