Native Human Collagen V protein (ab7537)

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Overview

Description

  • Nature
    Native
  • Source
    Native
  • Amino Acid Sequence
    • Accession
      P20908
    • Species
      Human
    • Molecular weight
      184 kDa
    • Additional sequence information
      Prepared from Human Placenta and is chromatographically and immunologically pure.

Associated products

Specifications

Our Abpromise guarantee covers the use of ab7537 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Collagen taken from human species.
  • Applications

    Western blot

    Immunoprecipitation

    ELISA

  • Form
    Liquid
  • Additional notes

    This product is free from other collagens, human serum proteins and non-collagen extracellular matrix proteins. This product reacts with anti-Collagen Type V. Reaction with anti-Collagen I, II, III, IV or VI is negligible (typically less than 1% cross reactivity was detected by ELISA).

    Collagen taken from human species.

    Denaturing and reducing conditions will greatly diminish reactivity and selectivity of this protein.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: 0.01% Sodium azide
    Constituent: 0.06% Acetic acid

General Info

  • Alternative names
    • AB collagen
    • Alpha 1 type V collagen
    • Alpha 2 type V collagen
    • CO5A1_HUMAN
    • COL5A1
    • Col5A2
    • COL5A2 protein
    • Col5A3
    • Collagen alpha 1(V) chain
    • Collagen alpha 2 (V) chain precursor
    • Collagen alpha 2(V) chain
    • Collagen alpha 3(V) chain
    • Collagen alpha-1(V) chain
    • Collagen fetal membrane A polypeptide
    • Collagen type V alpha 1
    • Collagen type V alpha 2
    • Collagen type V alpha 3
    • Collagen V alpha 2 polypeptide
    • CollagenV
    • MGC105115
    • OTTHUMP00000064637
    • Pro alpha 1 type V collagen
    • Pro alpha 3(V) collagen
    • Procollagen alpha 2(V)
    • Type V preprocollagen alpha 2 chain
    see all
  • Function
    Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.
  • Involvement in disease
    Ehlers-Danlos syndrome 1
    Ehlers-Danlos syndrome 2
  • Sequence similarities
    Belongs to the fibrillar collagen family.
    Contains 1 fibrillar collagen NC1 domain.
    Contains 1 laminin G-like domain.
  • Domain
    The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
  • Post-translational
    modifications
    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
    Sulfated on 40% of tyrosines.
  • Cellular localization
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

References

ab7537 has not yet been referenced specifically in any publications.

Publishing research using ab7537? Please let us know so that we can cite the reference in this datasheet.

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