Description

  • Product name

    Native human Factor V protein
    See all Factor V proteins and peptides
  • Biological activity

    Lot dependant, Determined by clotting assay. 

  • Purity

    > 95 % SDS-PAGE.
    Human Factor V is prepared from fresh frozen human plasma using immunoaffinity chromatography.
  • Expression system

    Native
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Native
    • Species

      Human

Specifications

Our Abpromise guarantee covers the use of ab62414 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Constituents: 50% dH2O, 50% ddH20, 50% Glycerol

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • Activated protein C cofactor
    • APC cofactor
    • Coagulation factor V
    • coagulation factor V (proaccelerin, labile factor)
    • coagulation factor V jinjiang A2 domain
    • Coagulation factor V light chain
    • F5
    • FA5_HUMAN
    • Factor V Leiden
    • FactorV
    • FVL
    • Labile factor
    • PCCF
    • Proaccelerin
    • proaccelerin, labile factor
    • Protein C cofactor
    • RPRGL1
    • THPH2
    see all
  • Function

    Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
  • Tissue specificity

    Plasma.
  • Involvement in disease

    Factor V deficiency
    Thrombophilia due to activated protein C resistance
    Budd-Chiari syndrome
    Ischemic stroke
    Pregnancy loss, recurrent, 1
  • Sequence similarities

    Belongs to the multicopper oxidase family.
    Contains 3 F5/8 type A domains.
    Contains 2 F5/8 type C domains.
    Contains 6 plastocyanin-like domains.
  • Domain

    Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.
  • Post-translational
    modifications

    Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
    Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
    Activated protein C inactivates factor V and factor Va by proteolytic degradation.
    Phosphorylation sites are present in the extracellular medium.
  • Cellular localization

    Secreted.
  • Information by UniProt

References

ab62414 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Answer

Thank you very much for your interest in our proteins. Unfortunately we do currently only have the human and bovine factor V in our catalogue. These are the ab62414 (human) and the ab62236 (bovine). Please let me know if you would like to receive more information in regards to this proteins. We are adding constantly more proteins to our catalogue and I hope we will have in the future these proteins. I am sorry however that for the moment we can't be more helpful. I wish you best of success with your research. Please do not hesitate to contact us again should you have any other questions.

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