Key features and details
- Expression system: Native
- Purity: > 95% SDS-PAGE
- Active: Yes
- Suitable for: SDS-PAGE, Functional Studies
Product nameNative human Factor V protein
See all Factor V proteins and peptides
Lot dependant, Determined by clotting assay.
Purity> 95 % SDS-PAGE.
Human Factor V is prepared from fresh frozen human plasma using immunoaffinity chromatography.
Protein lengthFull length protein
Our Abpromise guarantee covers the use of ab62414 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 50% dH2O, 50% Glycerol
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- Activated protein C cofactor
- APC cofactor
- Coagulation factor V
FunctionCentral regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
Involvement in diseaseFactor V deficiency
Thrombophilia due to activated protein C resistance
Pregnancy loss, recurrent, 1
Sequence similaritiesBelongs to the multicopper oxidase family.
Contains 3 F5/8 type A domains.
Contains 2 F5/8 type C domains.
Contains 6 plastocyanin-like domains.
DomainDomain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.
modificationsThrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
Activated protein C inactivates factor V and factor Va by proteolytic degradation.
Phosphorylation sites are present in the extracellular medium.
- Information by UniProt
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab62414 has not yet been referenced specifically in any publications.