Product nameNative human Factor Xa protein
See all Factor Xa proteins and peptides
Protein lengthFull length protein
Amino Acid Sequence
Amino acids41 to 488
Our Abpromise guarantee covers the use of ab81746 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activity<1% Factor Xa activity. Active site blocked with EGR.
Purity> 95 % SDS-PAGE.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.476% HEPES, 0.87% Sodium chloride
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- Activated factor Xa heavy chain
- Coagulation factor X
FunctionFactor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
Tissue specificityPlasma; synthesized in the liver.
Sequence similaritiesBelongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain.
modificationsThe vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
N- and O-glycosylated.
The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
- Information by UniProt
ab81746 has not yet been referenced specifically in any publications.