Key features and details
- Expression system: Native
- Suitable for: SDS-PAGE, Functional Studies
Product nameNative Human Factor XIa protein
See all Factor XIa proteins and peptides
Protein lengthFull length protein
Our Abpromise guarantee covers the use of ab62411 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 50% Glycerol, 50% Water
- coagulation factor XI
- Coagulation factor XIa light chain
FunctionFactor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
Tissue specificityIsoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
Involvement in diseaseDefects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.
Sequence similaritiesBelongs to the peptidase S1 family. Plasma kallikrein subfamily.
Contains 4 apple domains.
Contains 1 peptidase S1 domain.
modificationsActivated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.
- Information by UniProt
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab62411 has not yet been referenced specifically in any publications.