Native Human IgG FC fragment protein (ab90285)
Key features and details
- Expression system: Native
- Purity: > 95% SDS-PAGE
- Suitable for: SDS-PAGE
Description
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Product name
Native Human IgG FC fragment protein
See all Human IgG FC fragment proteins and peptides -
Biological activity
Shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 and 2 by FDA approved tests. -
Purity
> 95 % SDS-PAGE. -
Expression system
Native -
Protein length
Full length protein -
Animal free
No -
Nature
Native -
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Predicted molecular weight
50 kDa -
Additional sequence information
Prepared from plasma
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab90285 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Liquid -
Additional notes
Protein Determination: Extinction Coefficient (E) 0.1% at 280nm =1.46.
IgG is cleaved using Papain to product the Fc fragment. The IgG fc fragment does not bind antigen; however, it does contain the classic antigenic determinants and biological activity with respect to cytotrophic reactions, binding of complement and catabolic rate control.
Shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 and 2 by FDA approved tests.
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Preservative: 0.05% Sodium azide
Constituents: 0.79% Tris HCl, 1.16% Sodium chloride
General Info
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Relevance
The Fc region is the constant region on an immunoglobulin molecule, the area that is exactly the same on all antibodies. The Fc region is found on the heavy chains and is not involved in binding antigens.
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (12)
ab90285 has been referenced in 12 publications.
- Ma L et al. FOSL1 knockdown ameliorates DSS-induced inflammation and barrier damage in ulcerative colitis via MMP13 downregulation. Exp Ther Med 24:551 (2022). PubMed: 35978937
- Kamalakar A et al. JAGGED1 stimulates cranial neural crest cell osteoblast commitment pathways and bone regeneration independent of canonical NOTCH signaling. Bone 143:115657 (2021). PubMed: 32980561
- Qiu Y et al. Upregulation of AQP2 mediated by transcription factor FOXO1 inhibits TGF-ß-induced fibrosis in human urothelial cells. Exp Ther Med 22:1388 (2021). ChIP ; Human . PubMed: 34650636
- Vilhelmsson Timmermand O et al. A Conjugation Strategy to Modulate Antigen Binding and FcRn Interaction Leads to Improved Tumor Targeting and Radioimmunotherapy Efficacy with an Antibody Targeting Prostate-Specific Antigen. Cancers (Basel) 13:N/A (2021). PubMed: 34298682
- Bill M et al. EGFL7 Antagonizes NOTCH Signaling and Represents a Novel Therapeutic Target in Acute Myeloid Leukemia. Clin Cancer Res 26:669-678 (2020). PubMed: 31672772