Key features and details
- Expression system: Native
- Purity: > 95% SDS-PAGE
Product nameNative Human IgG1 protein
See all IgG1 proteins and peptides
Purity> 95 % SDS-PAGE.
Protein lengthFull length protein
Predicted molecular weight150 kDa
Additional sequence informationPrepared from Human plasma.
Our Abpromise guarantee covers the use of ab184886 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
In normal adult serum, the approximate percentage composition of IgG with respect to its subclasses is IgG1: 65 percent, Ig2: 23 percent, IgG3: 6 percent, and IgG4: 6 percent. Abnormal levels of one or more subclasses may be associated with autoimmune, anaphylatic and gut diseases, as well as with recurrent infection. Single arc by IEP against antisera to whole human serum and human IgG.
No reaction to antisera to human IgA, IgD, IgE, or IgM.
Prepared from plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Extinction Coefficient: 1.36
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Preparation and Storage
Stability and Storage
Shipped on Dry Ice. Store at -80°C.
Preservative: 0.05% Sodium azide
Constituents: 0.33% Sodium phosphate, 0.88% Sodium chloride
- Ig gamma 1 chain C region
- IgG heavy chain locus
RelevanceThere are four IgG subclasses (IgG1, 2, 3 and 4) in humans, named in order of their abundance in serum (IgG1 being the most abundant).
Cellular localizationSecreted. Cell membrane; Single-pass membrane protein
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab184886 has been referenced in 1 publication.
- Hong S et al. Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain. Brain Behav Immun 60:282-292 (2017). PubMed: 27833045