Native Human IgG2 protein (ab90284)
Key features and details
- Expression system: Native
- Purity: > 95% SDS-PAGE
- Suitable for: SDS-PAGE
Description
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Product name
Native Human IgG2 protein
See all IgG2 proteins and peptides -
Biological activity
Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 and 2 by FDA approved tests. -
Purity
> 95 % SDS-PAGE. -
Expression system
Native -
Protein length
Full length protein -
Animal free
No -
Nature
Native -
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Species
Human -
Predicted molecular weight
146 kDa -
Additional sequence information
Prepared from myeloma plasma.
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Specifications
Our Abpromise guarantee covers the use of ab90284 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Liquid -
Additional notes
Extinction Coefficient (E) 0.1% at 280nm =1.36.
Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 and 2 by FDA approved tests.
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
pH: 7.40
Preservative: 0.05% Sodium azide
Constituents: 0.9% Sodium chloride, 0.3% Sodium phosphate monobasic, monohydrate, 98% Water
General Info
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Alternative names
- Ig gamma-2 chain C region
- IGHG2
- immunoglobulin Gm2
see all -
Relevance
There are four IgG subclasses (IgG1, 2, 3 and 4) in humans, named in order of their abundance in serum (IgG1 being the most abundant). IgG2 is the only IgG subclass which passes through the placenta at a level generally lower than that found in the mother. A deficiency of IgG2 indicates a poor antibody response to bacterial polysaccharides and can lead to increased susceptibility to infections caused by encapsulated bacteria. -
Cellular localization
Secreted
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (8)
ab90284 has been referenced in 8 publications.
- Lu CH et al. The Fc?RIII Engagement Augments PMA-Stimulated Neutrophil Extracellular Traps (NETs) Formation by Granulocytes Partially via Cross-Talk between Syk-ERK-NF-?B and PKC-ROS Signaling Pathways. Biomedicines 9:N/A (2021). PubMed: 34572313
- Deb C et al. A 1-minute blood test detects decreased immune function and increased clinical risk in COVID-19 patients. Sci Rep 11:23491 (2021). PubMed: 34873223
- Dekimpe C et al. Determination of anti-ADAMTS-13 autoantibody titers in ELISA: Influence of ADAMTS-13 presentation and autoantibody detection. J Thromb Haemost 19:2248-2255 (2021). PubMed: 33728786
- Vidal M et al. Development of quantitative suspension array assays for six immunoglobulin isotypes and subclasses to multiple Plasmodium falciparum antigens. J Immunol Methods N/A:N/A (2018). PubMed: 29397157
- Doi T et al. Urinary IgG4 and Smad1 Are Specific Biomarkers for Renal Structural and Functional Changes in Early Stages of Diabetic Nephropathy. Diabetes 67:986-993 (2018). PubMed: 29490904
- Shiroishi M et al. Structure-function analyses of a stereotypic rheumatoid factor unravel the structural basis for germline-encoded antibody autoreactivity. J Biol Chem 293:7008-7016 (2018). PubMed: 29523691
- Sinkovits G et al. Concentration and Subclass Distribution of Anti-ADAMTS13 IgG Autoantibodies in Different Stages of Acquired Idiopathic Thrombotic Thrombocytopenic Purpura. Front Immunol 9:1646 (2018). PubMed: 30061898
- Masat E et al. Long-term exposure to Myozyme results in a decrease of anti-drug antibodies in late-onset Pompe disease patients. Sci Rep 6:36182 (2016). PubMed: 27812025