Product nameNative Human IgM Fc fragment protein
Biological activityThere is no reaction by IEP to antisera to kappa or lambda. Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 and 2 by FDA approved tests.
Purity> 95 % SDS-PAGE.
Protein lengthFull length protein
Our Abpromise guarantee covers the use of ab90287 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesExtinction Coefficient (E) 0.1% at 280nm =1.18.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.0536% PBS, 0.87% Sodium chloride
This product is an active protein and may elicit a biological response in vivo, handle with caution.
RelevanceImmunoglobulin M (IgM) is produced as a 900 kDa pentamer, which is an efficient complement binder. This antibody type is produced initially in the immune response and it is the first immunoglobulin class to be synthesized by a fetus or newborn. IgM antibodies do not cross the placenta. IgM concentration in blood is 0.12 g/l and its biological survival (plasma T1/2) is 5 days.
Cellular localizationCell Membrane and Secreted
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab90287 has been referenced in 1 publication.
- Augé E et al. New perspectives on corpora amylacea in the human brain. Sci Rep 7:41807 (2017). PubMed: 28155917