Native human Lactate Dehydrogenase protein (ab77857)

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Overview

Description

  • Nature
    Native
  • Source
    Native
  • Amino Acid Sequence
    • Species
      Human
    • Additional sequence information
      Source: Human Erythrocytes (Red Blood Cells)

Specifications

Our Abpromise guarantee covers the use of ab77857 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    The activity (Units/mL) and specific activity (Units/mg) are unique to the lot, representative of how pure the lot is (higher purity = higher specific activity).

    One unit will catalyze the transformation of one micromole of L-lactate to pyruvate per minute at 37°C and pH 8.55.

     

     

  • Applications

    Western blot

    Functional Studies

  • Form
    Liquid
  • Additional notes

    Activity: 530 Units/mL @ 37°C Dimension
    Protein: 4.25 mg Protein/mL (Coomassie)
    One unit will catalyze the transformation of one micromole of L-lactate to pyruvate per minute at 37°C and

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C. Do Not Freeze.

    pH: 7.50
    Constituents: 0.0292% EDTA, 41% Ammonium sulphate, 0.15% DTT, 0.32% Tris HCl

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Cell proliferation-inducing gene 19 protein
    • GSD11
    • L lactate dehydrogenase B chain
    • L-lactate dehydrogenase A chain
    • Lactate dehydrogenase A
    • Lactate dehydrogenase B
    • Lactate dehydrogenase H chain
    • Lactate dehydrogenase M
    • LDH A
    • LDH B
    • LDH H
    • LDH heart subunit
    • LDH M
    • LDH muscle subunit
    • LDH-A
    • LDH-M
    • LDH1
    • ldha
    • LDHA_HUMAN
    • LDHBD
    • LDHM
    • MS1111
    • PIG19
    • Proliferation inducing gene 19
    • Renal carcinoma antigen NY REN 46
    • Renal carcinoma antigen NY-REN-59
    • TRG 5
    • TRG5
    see all
  • Pathway
    Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.
  • Involvement in disease
    Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.
  • Sequence similarities
    Belongs to the LDH/MDH superfamily. LDH family.
  • Post-translational
    modifications
    ISGylated.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

References

ab77857 has not yet been referenced specifically in any publications.

Publishing research using ab77857? Please let us know so that we can cite the reference in this datasheet.

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