Name: Native Human TIMP1 protein
SKU: ab157282

Product name

Native Human TIMP1 protein
See all TIMP1 proteins and peptides
Protein length

Full length protein

Nature

Native
Source

Native
Amino Acid Sequence
- Accession
  
  P01033
- Species
  
  Human
- Sequence
  
  CTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQ ALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCS FVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQ LLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA
- Molecular weight
  
  28 kDa
- Amino acids
  
  24 to 207

Related Products

Our Abpromise guarantee covers the use of ab157282 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Applications

Western blot

SDS-PAGE
Purity

>90% by SDS-PAGE.
Purity: 92% (SDS-PAGE, Western blot).
Form

Liquid
Additional notes

Note: It is recommended to perform a preincubation of ~20 min. at 37°C to allow formation of the enzyme-inhibitor complex.
Concentration information loading...

Stability and Storage

Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

pH: 7.00
Preservative: 0.05% Sodium azide
Constituents: 0.05% Brij, 0.05% Calcium chloride, 0.00001% Zinc chloride, 0.79% Tris HCl, 1.17% Sodium chloride

Alternative names
- Clgi
- Collagenase inhibitor
- Collagenase inhibitor, Human
- EPA
- EPO
- Erythroid Potentiating Activity
- Erythroid-potentiating activity
- Fibroblast collagenase inhibitor
- FLJ90373
- HCI
- Human Collagenase Inhibitor
- Metalloproteinase inhibitor 1
- Metalloproteinase inhibitor 1 precursor
- OTTHUMP00000023214
- TIMP
- TIMP 1
- TIMP metallopeptidase inhibitor 1
- TIMP-1
- Timp1
- TIMP1 protein
- TIMP1_HUMAN
- Tissue Inhibitor of Metalloproteinase 1
- Tissue inhibitor of metalloproteinases
- Tissue inhibitor of metalloproteinases 1
- Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor
see all
Function

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
Sequence similarities

Belongs to the protease inhibitor I35 (TIMP) family.
Contains 1 NTR domain.
Post-translational
modifications

The activity of TIMP1 is dependent on the presence of disulfide bonds.
Cellular localization

Secreted.
Target information above from: UniProt accession P01033 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

Datasheet

ab157282 has not yet been referenced specifically in any publications.

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Native Human TIMP1 protein (ab157282)

Overview

Description

Associated products

Specifications

Preparation and Storage

General Info

Datasheets and documents

References

Customer reviews and Q&As