Product nameNative mouse Factor Xa protein
See all Factor Xa proteins and peptides
Protein lengthFull length protein
Amino Acid Sequence
Our Abpromise guarantee covers the use of ab95261 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityActivity is measured in a Factor Xa clotting assay and/or chromogenic substrate assay.
Purity> 95 % SDS-PAGE.
ab95261 is prepared by activating purified factor X with the factor X activator isolated from Russell's viper venom. Factor Xa is purified from the activation mixture by chromatography over benzamidine-Sepharose. Purity is determined by SDS-PAGE analysis.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Constituent: 50% Glycerol
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- Activated factor Xa heavy chain
- Coagulation factor X
FunctionFactor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
Tissue specificityPlasma; synthesized in the liver.
Sequence similaritiesBelongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain.
modificationsThe vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
N- and O-glycosylated.
The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
- Information by UniProt
ab95261 has not yet been referenced specifically in any publications.