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    native-rat-plasmin-protein-ab92813.pdf

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Cardiovascular Blood Fibrinolysis / Thrombolysis
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Native rat Plasmin protein (ab92813)

  • Datasheet
  • SDS
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SDS-PAGE - Native rat Plasmin protein (ab92813)

    Key features and details

    • Expression system: Native
    • Purity: > 95% SDS-PAGE
    • Active: Yes
    • Suitable for: SDS-PAGE

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    Description

    • Product name

      Native rat Plasmin protein
      See all Plasmin proteins and peptides
    • Biological activity

      Activity: 100% by definition (eluted from SBTI) 1 ug of plasmin corresponds to 0.024 CU or to 0.028 CTA-U.
    • Purity

      > 95 % SDS-PAGE.
      Prepared from plasminogen by activation with immobilized Human uPA.
    • Expression system

      Native
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Native
      • Species

        Rat

    Associated products

      Specifications

      Our Abpromise guarantee covers the use of ab92813 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      • Applications

        SDS-PAGE

      • Form

        Liquid
      • Additional notes

        Spectrophotometric Data: Ultraviolet: Absorbance (280nm) = 4.5 Epsilon 0.1% = 1.69 Active Concentration = 2.66 mg/mL
      • Concentration information loading...

      Preparation and Storage

      • Stability and Storage

        Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

        pH: 7.40
        Constituents: 2.38% HEPES, 0.58% Sodium chloride

        This product is an active protein and may elicit a biological response in vivo, handle with caution.

      General Info

      • Alternative names

        • Plasmin light chain B
        • Plasminogen
        • PLG
        • PLMN_HUMAN
      • Function

        Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
        Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.
      • Tissue specificity

        Present in plasma and many other extracellular fluids. It is synthesized in the liver.
      • Involvement in disease

        Plasminogen deficiency
      • Sequence similarities

        Belongs to the peptidase S1 family. Plasminogen subfamily.
        Contains 5 kringle domains.
        Contains 1 PAN domain.
        Contains 1 peptidase S1 domain.
      • Domain

        Kringle domains mediate interaction with CSPG4.
      • Post-translational
        modifications

        N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity).
        In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide.
      • Cellular localization

        Secreted. Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.
      • Target information above from: UniProt accession P00747 The UniProt Consortium
        The Universal Protein Resource (UniProt) in 2010
        Nucleic Acids Res. 38:D142-D148 (2010) .

        Information by UniProt

      Images

      • SDS-PAGE - Native rat Plasmin protein (ab92813)
        SDS-PAGE - Native rat Plasmin protein (ab92813)
        10% SDS-PAGE analysis of ab92813
        Lane 1: ab92813 (3µg) Reduced
        Lane 2: ab92813 (3µg) + Antiplasmin (10µg) Reduced
        Lane 3: ab92813 (3µg) Non-reduced
        Lane 4: ab92813 (3µg) + Antiplasmin (10µg) Non-reduced
        Lane 5: Molecular weight markers

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (0)

      Publishing research using ab92813? Please let us know so that we can cite the reference in this datasheet.

      ab92813 has not yet been referenced specifically in any publications.

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