Native Renin/Prorenin double Depleted Plasma (ab188462)
- Datasheet
- References
- Protocols
Description
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Product name
Native Renin/Prorenin double Depleted Plasma
See all Renin proteins and peptides -
Expression system
Native -
Protein length
Full length protein -
Animal free
No -
Nature
Native -
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Species
Human -
Additional sequence information
Human Renin/Prorenin double Depleted Plasma prepared from frozen Human plasma using immobilized anti-Human Renin IgG.
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Description
Native Human Renin protein
Specifications
Our Abpromise guarantee covers the use of ab188462 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Form
Liquid -
Additional notes
Concentration: <0.1 ng/ml Renin, <0.1 ng/ml Prorenin Antigen
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on Dry Ice. Store at -80°C.
General Info
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Alternative names
- Angiotensin forming enzyme
- Angiotensin forming enzyme precursor
- Angiotensinogenase
see all -
Function
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. -
Involvement in disease
Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia. -
Sequence similarities
Belongs to the peptidase A1 family. -
Cellular localization
Secreted. Membrane. Associated to membranes via binding to ATP6AP2. - Information by UniProt
Datasheets and documents
References
ab188462 has not yet been referenced specifically in any publications.
