Overview

  • Product name

    Anti-Natriuretic peptides A antibody
    See all Natriuretic peptides A primary antibodies
  • Description

    Rabbit polyclonal to Natriuretic peptides A
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC, ICC/IF, RIAmore details
  • Species reactivity

    Reacts with: Mouse, Rat
    Predicted to work with: Guinea pig, Chimpanzee, Gorilla
  • Immunogen

    Synthetic peptide corresponding to Rat Natriuretic peptides A aa 124-151.
    Sequence:

    SLRRSSCFGGRIDRIGAQSGLGCNSFRY


    Database link: P01161

Properties

Applications

Our Abpromise guarantee covers the use of ab14348 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC Use at an assay dependent dilution.
ICC/IF Use at an assay dependent dilution. PubMed: 20544856
RIA 1/3000.

Target

  • Function

    Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
  • Involvement in disease

    Atrial standstill 2
    Atrial fibrillation, familial, 6
  • Sequence similarities

    Belongs to the natriuretic peptide family.
  • Post-translational
    modifications

    Cleaved by CORIN upon secretion to produce the functional hormone.
    Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • ANF antibody
    • ANF_HUMAN antibody
    • ANP antibody
    • ATFB6 antibody
    • Atrial natriuretic factor antibody
    • Atrial natriuretic peptide antibody
    • Atriopeptin antibody
    • Cardiodilatin antibody
    • Cardiodilatin related peptide antibody
    • Cardiodilatin-related peptide antibody
    • Cardionatrin antibody
    • CDD ANF antibody
    • CDD antibody
    • CDD-ANF antibody
    • CDP antibody
    • Natriuretic peptide A antibody
    • Natriuretic peptide precursor A antibody
    • NPPA antibody
    • PND antibody
    • Prepronatriodilatin antibody
    see all

References

This product has been referenced in:

  • Ravi V  et al. Systematic evaluation of the adaptability of the non-radioactive SUnSET assay to measure cardiac protein synthesis. Sci Rep 8:4587 (2018). Read more (PubMed: 29545554) »
  • Putinski C  et al. Caspase Cleavage of Gelsolin Is an Inductive Cue for Pathologic Cardiac Hypertrophy. J Am Heart Assoc 7:e010404 (2018). Read more (PubMed: 30486716) »
See all 6 Publications for this product

Customer reviews and Q&As

Application
Immunocytochemistry
Sample
Rat Cell (astrocytes)
Specification
astrocytes
Fixative
Paraformaldehyde
Blocking step
Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10%

Abcam user community

Verified customer

Submitted Jan 05 2006

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up