Anti-Natriuretic peptides A antibody - C-terminal (ab190001)

Overview

  • Product name

    Anti-Natriuretic peptides A antibody - C-terminal
    See all Natriuretic peptides A primary antibodies
  • Description

    Goat polyclonal to Natriuretic peptides A - C-terminal
  • Host species

    Goat
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
    Predicted to work with: Sheep, Horse, Guinea pig, Cow, Cat, Dog, Pig, Orangutan
  • Immunogen

    Synthetic peptide corresponding to Human proANP aa 137-150 (C terminal). (NP_006163.1)
    Sequence:

    RIGAQSGLGCNSFR


    Database link: P01160

  • Positive control

    • Human heart tissue, Mouse heart tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab190001 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml.
WB Use a concentration of 0.01 - 0.03 µg/ml. Detects a band of approximately 19 kDa (predicted molecular weight: 17 kDa).

Target

  • Function

    Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
  • Involvement in disease

    Atrial standstill 2
    Atrial fibrillation, familial, 6
  • Sequence similarities

    Belongs to the natriuretic peptide family.
  • Post-translational
    modifications

    Cleaved by CORIN upon secretion to produce the functional hormone.
    Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • ANF antibody
    • ANF_HUMAN antibody
    • ANP antibody
    • ATFB6 antibody
    • Atrial natriuretic factor antibody
    • Atrial natriuretic peptide antibody
    • Atriopeptin antibody
    • Cardiodilatin antibody
    • Cardiodilatin related peptide antibody
    • Cardiodilatin-related peptide antibody
    • Cardionatrin antibody
    • CDD ANF antibody
    • CDD antibody
    • CDD-ANF antibody
    • CDP antibody
    • Natriuretic peptide A antibody
    • Natriuretic peptide precursor A antibody
    • NPPA antibody
    • PND antibody
    • Prepronatriodilatin antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human heart tissue, labeling Natriuretic peptides A with ab190001 at 5 µg/ml.

  • Anti-Natriuretic peptides A antibody - C-terminal (ab190001) at 0.03 µg/ml + Mouse heart lysate at 35 µg

    Developed using the ECL technique.

    Predicted band size: 17 kDa
    Observed band size: 19 kDa
    why is the actual band size different from the predicted?



    Primary incubation was 1 hour.

References

ab190001 has not yet been referenced specifically in any publications.

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