Anti-Natriuretic peptides A antibody [M622709] (ab2093)
Key features and details
- Mouse monoclonal [M622709] to Natriuretic peptides A
- Suitable for: IHC-P, Flow Cyt, RIA
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-Natriuretic peptides A antibody [M622709]
See all Natriuretic peptides A primary antibodies -
Description
Mouse monoclonal [M622709] to Natriuretic peptides A -
Host species
Mouse -
Specificity
Affinity Constant: 2.2 x 1010 L/M -
Tested applications
Suitable for: IHC-P, Flow Cyt, RIAmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human Natriuretic peptides A conjugated to bovine serum albumin.
Database link: P01160 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Preservative: 0.1% Sodium azide -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
M622709 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab2093 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P | (2) |
Use at an assay dependent concentration.
|
Flow Cyt |
Use at an assay dependent concentration. PubMed: 20080656
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
|
RIA |
Use at an assay dependent concentration.
|
Notes |
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IHC-P
Use at an assay dependent concentration. |
Flow Cyt
Use at an assay dependent concentration. PubMed: 20080656 ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
RIA
Use at an assay dependent concentration. |
Target
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Function
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. -
Involvement in disease
Atrial standstill 2
Atrial fibrillation, familial, 6 -
Sequence similarities
Belongs to the natriuretic peptide family. -
Post-translational
modificationsCleaved by CORIN upon secretion to produce the functional hormone.
Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 4878 Human
- Omim: 108780 Human
- SwissProt: P01160 Human
- Unigene: 75640 Human
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Alternative names
- ANF antibody
- ANF_HUMAN antibody
- ANP antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab2093 has been referenced in 2 publications.
- Ahmed A et al. Natriuretic peptide system expression in murine and human submandibular salivary glands: a study of the spatial localisation of ANB, BNP, CNP and their receptors. J Mol Histol 51:3-13 (2020). PubMed: 31722080
- Therrien JP et al. A gene therapy approach for long-term normalization of blood pressure in hypertensive mice by ANP-secreting human skin grafts. Proc Natl Acad Sci U S A 107:1178-83 (2010). IHC-P, Flow Cyt ; Human . PubMed: 20080656