The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
The product has been prepared from bovine placenta and is chromatographically and immunologically pure.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 4.50 Constituent: 3% Acetic acid
Alpha 1 type III collagen
Alpha1 (III) collagen
Collagen alpha 1(III) chain
Collagen alpha-1(III) chain
Collagen III alpha 1 chain precursor
Collagen III alpha 1 polypeptide
Collagen type III alpha
Collagen type III alpha 1
Collagen type III alpha 1 (Ehlers Danlos syndrome type IV autosomal dominant)
Collagen type III alpha 1 chain
Ehlers Danlos syndrome type IV, autosomal dominant
Type III collagen
Collagen type III occurs in most soft connective tissues along with type I collagen.
Involvement in disease
Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type 3 (EDS3) [MIM:130020]; also known as benign hypermobility syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS3 is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity. Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type 4 (EDS4) [MIM:130050]. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS4 is the most severe form of the disease. It is characterized by the joint and dermal manifestations as in other forms of the syndrome, characteristic facial features (acrogeria) in most patients, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas. Defects in COL3A1 are a cause of susceptibility to aortic aneurysm abdominal (AAA) [MIM:100070]. AAA is a common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells.
Belongs to the fibrillar collagen family. Contains 1 fibrillar collagen NC1 domain. Contains 1 VWFC domain.
Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
Secreted > extracellular space > extracellular matrix.