The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Specific activity: 700-1300 units/mg.
Specific activity is determined by Factor X clotting assay (PT). One unit of activity is equivalent to the factor X activity in one milliter of normal plasma.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Constituents: ddH20, 50% Glycerol
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Activated factor Xa heavy chain
Coagulation factor X
Factor X deficiency
Stuart Prower factor
Stuart-Prower factor deficiency
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
Plasma; synthesized in the liver.
Involvement in disease
Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.
Belongs to the peptidase S1 family. Contains 2 EGF-like domains. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 1 peptidase S1 domain.
The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. N- and O-glycosylated. The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway). The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.