This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitute with 25.8ul distilled water.
84 kDa myeloperoxidase
89 kDa myeloperoxidase
Myeloperoxidase heavy chain
Myeloperoxidase light chain
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
Involvement in disease
Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.