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Access a highly defined, scalable, and consistent source of human central nervous system (CNS) neurons at Abcam. We are introducing ioNEURONS/glut, human-induced glutamatergic neurons cells through our partnership with Bit Bio, providing you with a high-quality human model for research, drug development and high-throughput screening. ioNEURONS/glut cells have been reprogrammed from human induced pluripotent stem cells (hiPSC) using a precise reprogramming technology: opti-ox1 (optimized inducible overexpression).
Optimized inducible overexpression (opti-ox) technology
The widespread use of hiPSC-derived, mature cell types has been restricted by complex and suboptimal differentiation protocols. By applying a cellular reprogramming approach supported by a uniquely engineered genetic switch, opti-ox, these restrictions have been largely overcome.
This proprietary technology enables homogeneous and synchronous differentiation of entire hiPSC cultures through tightly controlled expression of selected transcription factors. Opti-ox cellular reprogramming enables the consistent manufacture of homogenous and mature hiPSCs derived functional cells within days, offering access to the highest quality cellular models with simple protocols.
ioNEURONS/glut cells provide you with:
Consistency: Batch-to-batch reproducibility and homogeneity create a stable human model for excitatory neuronal activity and disease.
Speed: Ready for experimentation as early as two days post revival and allow the formation of functional neuronal networks at 17 days.
Scalability: Industrial scale quantities allow the cells to be used in a range of applications, from research to screening purposes.
Ease of Use: Cells arrive programmed to rapidly mature upon revival with only one medium required in a two-step protocol.
Our range is constantly expanding, and we will be introducing additional cell types soon.
1. Pawlowski, M. Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes. Stem Cell Reports. 8(4), 803-812 (2017).