Necrosulfonamide, necroptosis inhibitor (ab143839)
Key features and details
- Potent, selective necroptosis inhibitor. MLKL blocker.
- CAS Number: 432531-71-0
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Necrosulfonamide, necroptosis inhibitor -
Description
Potent, selective necroptosis inhibitor. MLKL blocker. -
Purity
> 98% -
CAS Number
432531-71-0 -
Chemical structure
Properties
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Chemical name
(E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide -
Molecular weight
461.47 -
Molecular formula
C18H15N5O6S2 -
PubChem identifier
1566236 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(S3)[N+](=O)[O-] -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (10)
ab143839 has been referenced in 10 publications.
- Wu N et al. Progesterone prevents HGSOC by promoting precancerous cell pyroptosis via inducing fibroblast paracrine. iScience 26:106523 (2023). PubMed: 37123232
- Li Z et al. Circular RNA circBLNK promotes osteosarcoma progression and inhibits ferroptosis in osteosarcoma cells by sponging miR‑188‑3p and regulating GPX4 expression. Oncol Rep 50:N/A (2023). PubMed: 37711054
- André-Grégoire G et al. Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma. iScience 25:105118 (2022). PubMed: 36185361
- Wang Q et al. Epigenetic Regulation of RIP3 Suppresses Necroptosis and Increases Resistance to Chemotherapy in NonSmall Cell Lung Cancer. Transl Oncol 13:372-382 (2020). PubMed: 31887632
- Rashidi M et al. The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1ß Release. J Immunol 203:736-748 (2019). PubMed: 31209100
- Bai T et al. Sigma-1 receptor protects against ferroptosis in hepatocellular carcinoma cells. J Cell Mol Med 23:7349-7359 (2019). PubMed: 31507082
- Xiao X et al. miR-212-5p attenuates ferroptotic neuronal death after traumatic brain injury by targeting Ptgs2. Mol Brain 12:78 (2019). PubMed: 31533781
- Luo M et al. miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma. Cell Death Differ 25:1457-1472 (2018). PubMed: 29348676
- Murai S et al. A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs. Nat Commun 9:4457 (2018). PubMed: 30367066
- Lusthaus M et al. Receptor-Interacting Protein Kinases 1 and 3, and Mixed Lineage Kinase Domain-Like Protein Are Activated by Sublytic Complement and Participate in Complement-Dependent Cytotoxicity. Front Immunol 9:306 (2018). PubMed: 29527209