Recombinant Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (ab134959)
![Western blot - Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (ab134959)](https://www.abcam.com/ps/products/134/ab134959/Images/ab134959-149191-anti-thromboxane-a2-receptor-antibody-epr7336-western-blot.jpg "Western blot - Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (ab134959)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR7336] to Thromboxane A2 receptor/TBXA2R
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
Overview
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Product name
Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336]
See all Thromboxane A2 receptor/TBXA2R primary antibodies -
Description
Rabbit monoclonal [EPR7336] to Thromboxane A2 receptor/TBXA2R -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details
Unsuitable for: IHC-P or IP -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat
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Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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Positive control
- Human platelet, fetal kidney and fetal heart lysates.
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General notes
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20ºC. -
Storage buffer
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading... -
Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
EPR7336 -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab134959 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | (1) |
1/1000 - 1/10000. Predicted molecular weight: 37 kDa.
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| Notes |
|---|
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WB
1/1000 - 1/10000. Predicted molecular weight: 37 kDa. |
Application notes
Is unsuitable for IHC-P or IP.
Target
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Function
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase. -
Involvement in disease
Defects in TBXA2R are the cause of susceptibility to bleeding disorder platelet-type 13 (BDPLT13) [MIM:614009]. BDPLT13 is a disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 6915 Human
- Entrez Gene: 21390 Mouse
- Entrez Gene: 24816 Rat
- Omim: 188070 Human
- SwissProt: P21731 Human
- SwissProt: P30987 Mouse
- SwissProt: P34978 Rat
- Unigene: 442530 Human
see all -
Alternative names
- BDPLT13 antibody
- Prostanoid TP receptor antibody
- TA2R_HUMAN antibody
see all
Images
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Western blot - Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (ab134959)All lanes : Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (ab134959) at 1/1000 dilution
Lane 1 : Human platelet lysate
Lane 2 : Human fetal kidney lysate
Lane 3 : Human fetal heart lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : HRP labelled goat anti rabbit at 10 µg
Predicted band size: 37 kDa -
![Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (ab134959)](https://www.abcam.com/ps/products/134/ab134959/Images/ab134959-2-benefits-of-recombinant-antibodies.png)
Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (ab134959)
Datasheets and documents
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Datasheet download
References (3)
ab134959 has been referenced in 3 publications.
- Sun S et al. Overexpressed microRNA-103a-3p inhibits acute lower-extremity deep venous thrombosis via inhibition of CXCL12. IUBMB Life 72:492-504 (2020). PubMed: 31613419
- Razak AA et al. Impaired vasocontractile responses to adenosine in chorionic vessels of human term placenta from pregnant women with pre-existing and gestational diabetes. Diab Vasc Dis Res 15:528-540 (2018). PubMed: 30130976
- Wang P et al. Inflammatory mediators mediate airway smooth muscle contraction through a G protein-coupled receptor-transmembrane protein 16A-voltage-dependent Ca2+ channel axis and contribute to bronchial hyperresponsiveness in asthma. J Allergy Clin Immunol 141:1259-1268.e11 (2018). WB . PubMed: 28754608
