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    thromboxane-a2-receptortbxa2r-antibody-epr7336-ab134959.pdf

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RecombinantRabMAb

Recombinant Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (ab134959)

  • Datasheet
  • SDS
Reviews (1) Submit a question References (3)

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Western blot - Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (ab134959)
  • Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (ab134959)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR7336] to Thromboxane A2 receptor/TBXA2R
  • Suitable for: WB
  • Reacts with: Human

Conjugates logo Related conjugates and formulations

Carrier Free

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Overview

  • Product name

    Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336]
    See all Thromboxane A2 receptor/TBXA2R primary antibodies
  • Description

    Rabbit monoclonal [EPR7336] to Thromboxane A2 receptor/TBXA2R
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: IHC-P or IP
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

  • Positive control

    • Human platelet, fetal kidney and fetal heart lysates.
  • General notes

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20ºC.
  • Storage buffer

    pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant
  • Concentration information loading...
  • Purity

    Tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    EPR7336
  • Isotype

    IgG
  • Research areas

    • Cardiovascular
    • Blood
    • Platelets
    • Cardiovascular
    • Atherosclerosis
    • Lipoprotein metabolism
    • Cardiovascular
    • Atherosclerosis
    • Thrombosis
    • Platelets
    • Cardiovascular
    • Vasculature
    • Vasoconstriction
    • Other
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Lipoprotein metabolism
    • Metabolism
    • Types of disease
    • Heart disease

Associated products

  • Alternative Versions

    • Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] - BSA and Azide free (ab248753)
  • Isotype control

    • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab134959 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB (1)
1/1000 - 1/10000. Predicted molecular weight: 37 kDa.
Notes
WB
1/1000 - 1/10000. Predicted molecular weight: 37 kDa.
Application notes
Is unsuitable for IHC-P or IP.

Target

  • Function

    Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.
  • Involvement in disease

    Defects in TBXA2R are the cause of susceptibility to bleeding disorder platelet-type 13 (BDPLT13) [MIM:614009]. BDPLT13 is a disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Target information above from: UniProt accession P21731 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 6915 Human
    • Entrez Gene: 21390 Mouse
    • Entrez Gene: 24816 Rat
    • Omim: 188070 Human
    • SwissProt: P21731 Human
    • SwissProt: P30987 Mouse
    • SwissProt: P34978 Rat
    • Unigene: 442530 Human
    • Unigene: 4545 Mouse
    • Unigene: 44614 Rat
    see all
  • Alternative names

    • BDPLT13 antibody
    • Prostanoid TP receptor antibody
    • TA2R_HUMAN antibody
    • Tbxa2r antibody
    • Thromboxane A2 receptor antibody
    • TP receptor antibody
    • TXA2 R antibody
    • TXA2-R antibody
    • TXA2R antibody
    see all

Images

  • Western blot - Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (ab134959)
    Western blot - Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (ab134959)
    All lanes : Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (ab134959) at 1/1000 dilution

    Lane 1 : Human platelet lysate
    Lane 2 : Human fetal kidney lysate
    Lane 3 : Human fetal heart lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    All lanes : HRP labelled goat anti rabbit at 10 µg

    Predicted band size: 37 kDa

  • Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (ab134959)
    Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (ab134959)

Protocols

  • Western blot protocols

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (3)

Publishing research using ab134959? Please let us know so that we can cite the reference in this datasheet.

ab134959 has been referenced in 3 publications.

  • Sun S  et al. Overexpressed microRNA-103a-3p inhibits acute lower-extremity deep venous thrombosis via inhibition of CXCL12. IUBMB Life 72:492-504 (2020). PubMed: 31613419
  • Razak AA  et al. Impaired vasocontractile responses to adenosine in chorionic vessels of human term placenta from pregnant women with pre-existing and gestational diabetes. Diab Vasc Dis Res 15:528-540 (2018). PubMed: 30130976
  • Wang P  et al. Inflammatory mediators mediate airway smooth muscle contraction through a G protein-coupled receptor-transmembrane protein 16A-voltage-dependent Ca2+ channel axis and contribute to bronchial hyperresponsiveness in asthma. J Allergy Clin Immunol 141:1259-1268.e11 (2018). WB . PubMed: 28754608

Customer reviews and Q&As

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Western blot abreview for Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336]

Average
Abreviews
Abreviews
abreview image
Application
Western blot
Sample
Human Cell lysate - whole cell (Vascular smooth muscle cells)
Gel Running Conditions
Reduced Denaturing
Loading amount
30 µg
Specification
Vascular smooth muscle cells
Blocking step
Milk as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 21°C
Read More
The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

Abcam user community

Verified customer

Submitted Oct 22 2018

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