Anti-Nav1.6/SCN8A antibody (ab181759)
Key features and details
- Rabbit polyclonal to Nav1.6/SCN8A
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Nav1.6/SCN8A antibody
See all Nav1.6/SCN8A primary antibodies -
Description
Rabbit polyclonal to Nav1.6/SCN8A -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide within Human Nav1.6/SCN8A. The exact sequence is proprietary.
Database link: Q9UQD0 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab181759 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
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Notes |
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IHC-P
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
Target
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Function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation. -
Tissue specificity
Isoform 5 is expressed in non-neuronal tissues, such as monocytes/macrophages. -
Sequence similarities
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily.
Contains 1 IQ domain. -
Domain
The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. -
Post-translational
modificationsMay be ubiquitinated by NEDD4L; which would promote its endocytosis. -
Cellular localization
Membrane and Cytoplasmic vesicle. Some vesicles are localized adjacent to melanoma invadopodia and macrophage podosomes. Does not localize to the plasma membrane. - Information by UniProt
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Database links
- Entrez Gene: 6334 Human
- Entrez Gene: 20273 Mouse
- Entrez Gene: 29710 Rat
- Omim: 600702 Human
- SwissProt: Q9UQD0 Human
- SwissProt: Q9WTU3 Mouse
- SwissProt: O88420 Rat
- Unigene: 710638 Human
see all -
Alternative names
- CerIII antibody
- CIAT antibody
- EIEE13 antibody
see all
Protocols
Datasheets and documents
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Datasheet download
References (0)
ab181759 has not yet been referenced specifically in any publications.