Key features and details
- Rabbit polyclonal to Nav1.6/SCN8A
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Nav1.6/SCN8A antibody
See all Nav1.6/SCN8A primary antibodies
DescriptionRabbit polyclonal to Nav1.6/SCN8A
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Synthetic peptide within Human Nav1.6/SCN8A. The exact sequence is proprietary.
Database link: Q9UQD0
This product was previously labelled as Nav1.6
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Concentration information loading...
PurityProtein A purified
FunctionMediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation.
Tissue specificityIsoform 5 is expressed in non-neuronal tissues, such as monocytes/macrophages.
Sequence similaritiesBelongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily.
Contains 1 IQ domain.
DomainThe sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
modificationsMay be ubiquitinated by NEDD4L; which would promote its endocytosis.
Cellular localizationMembrane and Cytoplasmic vesicle. Some vesicles are localized adjacent to melanoma invadopodia and macrophage podosomes. Does not localize to the plasma membrane.
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ab181759 has not yet been referenced specifically in any publications.