Key features and details
- Rabbit polyclonal to Nav1.6/SCN8A
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-Nav1.6/SCN8A antibody
See all Nav1.6/SCN8A primary antibodies
DescriptionRabbit polyclonal to Nav1.6/SCN8A
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide corresponding to Human Nav1.6/SCN8A.
This product was previously labelled as Nav1.6.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferConstituent: Whole serum
Concentration information loading...
FunctionMediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation.
Tissue specificityIsoform 5 is expressed in non-neuronal tissues, such as monocytes/macrophages.
Sequence similaritiesBelongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily.
Contains 1 IQ domain.
DomainThe sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
modificationsMay be ubiquitinated by NEDD4L; which would promote its endocytosis.
Cellular localizationMembrane and Cytoplasmic vesicle. Some vesicles are localized adjacent to melanoma invadopodia and macrophage podosomes. Does not localize to the plasma membrane.
- Information by UniProt
- CerIII antibody
- CIAT antibody
- EIEE13 antibody
ab65166 has been referenced in 6 publications.
- Fei H et al. MicroRNA-18 promotes apoptosis of islet ß-cells via targeting NAV1. Exp Ther Med 18:389-396 (2019). PubMed: 31258677
- Arechederra M et al. Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer. Nat Commun 9:3164 (2018). PubMed: 30089774
- Zhu H et al. Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis. Sci Rep 6:38108 (2016). IHC-P ; Rat . PubMed: 27905510
- Wen M et al. Upregulation of RBFOX1 in the malformed cortex of patients with intractable epilepsy and in cultured rat neurons. Int J Mol Med 35:597-606 (2015). IHC-P . PubMed: 25571999
- Gehman LT et al. The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function. Genes Dev 26:445-60 (2012). WB ; Mouse . PubMed: 22357600
- Hitt BD et al. BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization. Mol Neurodegener 5:31 (2010). WB ; Mouse . PubMed: 20731874