Key features and details
- Rabbit polyclonal to Nav1.6/SCN8A
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-Nav1.6/SCN8A antibody
See all Nav1.6/SCN8A primary antibodies
DescriptionRabbit polyclonal to Nav1.6/SCN8A
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide corresponding to Human Nav1.6/SCN8A.
This product was previously labelled as Nav1.6.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferConstituent: Whole serum
Concentration information loading...
FunctionMediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation.
Tissue specificityIsoform 5 is expressed in non-neuronal tissues, such as monocytes/macrophages.
Sequence similaritiesBelongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily.
Contains 1 IQ domain.
DomainThe sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
modificationsMay be ubiquitinated by NEDD4L; which would promote its endocytosis.
Cellular localizationMembrane and Cytoplasmic vesicle. Some vesicles are localized adjacent to melanoma invadopodia and macrophage podosomes. Does not localize to the plasma membrane.
- Information by UniProt
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ab65166 has been referenced in 7 publications.
- Tan YX et al. Exercise-Induced Cognitive Improvement Is Associated with Sodium Channel-Mediated Excitability in APP/PS1 Mice. Neural Plast 2020:9132720 (2020). PubMed: 32256560
- Fei H et al. MicroRNA-18 promotes apoptosis of islet ß-cells via targeting NAV1. Exp Ther Med 18:389-396 (2019). PubMed: 31258677
- Arechederra M et al. Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer. Nat Commun 9:3164 (2018). PubMed: 30089774
- Zhu H et al. Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis. Sci Rep 6:38108 (2016). IHC-P ; Rat . PubMed: 27905510
- Wen M et al. Upregulation of RBFOX1 in the malformed cortex of patients with intractable epilepsy and in cultured rat neurons. Int J Mol Med 35:597-606 (2015). IHC-P . PubMed: 25571999
- Gehman LT et al. The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function. Genes Dev 26:445-60 (2012). WB ; Mouse . PubMed: 22357600
- Hitt BD et al. BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization. Mol Neurodegener 5:31 (2010). WB ; Mouse . PubMed: 20731874