Anti-Nav1.6/SCN8A antibody (ab65166)
Key features and details
- Rabbit polyclonal to Nav1.6/SCN8A
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-Nav1.6/SCN8A antibody
See all Nav1.6/SCN8A primary antibodies -
Description
Rabbit polyclonal to Nav1.6/SCN8A -
Host species
Rabbit -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Synthetic peptide corresponding to Human Nav1.6/SCN8A.
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General notes
This product was previously labelled as Nav1.6.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Constituent: Whole serum -
Concentration information loading... -
Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Target
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Function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation. -
Tissue specificity
Isoform 5 is expressed in non-neuronal tissues, such as monocytes/macrophages. -
Sequence similarities
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily.
Contains 1 IQ domain. -
Domain
The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. -
Post-translational
modificationsMay be ubiquitinated by NEDD4L; which would promote its endocytosis. -
Cellular localization
Membrane and Cytoplasmic vesicle. Some vesicles are localized adjacent to melanoma invadopodia and macrophage podosomes. Does not localize to the plasma membrane. - Information by UniProt
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Database links
- Entrez Gene: 6334 Human
- Entrez Gene: 20273 Mouse
- Entrez Gene: 29710 Rat
- Omim: 600702 Human
- SwissProt: Q9UQD0 Human
- SwissProt: Q9WTU3 Mouse
- SwissProt: O88420 Rat
- Unigene: 710638 Human
see all -
Alternative names
- CerIII antibody
- CIAT antibody
- EIEE13 antibody
see all
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
References (7)
ab65166 has been referenced in 7 publications.
- Tan YX et al. Exercise-Induced Cognitive Improvement Is Associated with Sodium Channel-Mediated Excitability in APP/PS1 Mice. Neural Plast 2020:9132720 (2020). PubMed: 32256560
- Fei H et al. MicroRNA-18 promotes apoptosis of islet ß-cells via targeting NAV1. Exp Ther Med 18:389-396 (2019). PubMed: 31258677
- Arechederra M et al. Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer. Nat Commun 9:3164 (2018). PubMed: 30089774
- Zhu H et al. Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis. Sci Rep 6:38108 (2016). IHC-P ; Rat . PubMed: 27905510
- Wen M et al. Upregulation of RBFOX1 in the malformed cortex of patients with intractable epilepsy and in cultured rat neurons. Int J Mol Med 35:597-606 (2015). IHC-P . PubMed: 25571999
- Gehman LT et al. The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function. Genes Dev 26:445-60 (2012). WB ; Mouse . PubMed: 22357600
- Hitt BD et al. BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization. Mol Neurodegener 5:31 (2010). WB ; Mouse . PubMed: 20731874
