Product nameAnti-Nav1.7 antibody
See all Nav1.7 primary antibodies
DescriptionRabbit polyclonal to Nav1.7
Tested applicationsSuitable for: WB, ICC/IFmore details
Species reactivityReacts with: Mouse, Rat
Synthetic peptide within Mouse Nav1.7. The exact sequence is proprietary. Carrier-protein conjugated. Center region.
Database link: Q62205
- WB: Rat and mouse brain tissue extracts. ICC/IF: Rat primary cortical neuron cells.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.025% Proclin 300
Constituents: PBS, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab272931 in the following tested applications.
|WB||1/500 - 1/3000.|
|ICC/IF||1/100 - 1/1000.|
FunctionMediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784).
Tissue specificityExpressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion.
Involvement in diseasePrimary erythermalgia
Indifference to pain, congenital, autosomal recessive
Paroxysmal extreme pain disorder
Generalized epilepsy with febrile seizures plus 7
Febrile seizures, familial, 3B
Sequence similaritiesBelongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily.
Contains 1 IQ domain.
DomainThe sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
modificationsPhosphorylation at Ser-1490 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents.
Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4.
Cellular localizationCell membrane. Cell projection. In neurite terminals.
- Information by UniProt
- ETHA antibody
- GEFSP7 antibody
- hNE Na antibody
All lanes : Anti-Nav1.7 antibody (ab272931) at 1/3000 dilution
Lane 1 : Mouse brain tissue extracts
Lane 2 : Rat brain tissue extracts
Lysates/proteins at 30 µg per lane.
All lanes : HRP-conjugated anti-rabbit IgG
4% PFA-fixed rat primary cortical neuron cells stained for Nav1.7 using ab272931 at 1/500 dilution in ICC/IF (green). Red: Tau. Blue: DAPI.
ab272931 has not yet been referenced specifically in any publications.