Key features and details
- AMPA / kainate antagonist. 1 ml water soluble pack.
- CAS Number: 118876-58-7
- Purity: > 98%
- Soluble in 1 ml water to give specified mM/ml concentration
- Form / State: Solid
- Source: Synthetic
Product nameNBQX disodium salt (mM/ml), AMPA / kainate antagonist
DescriptionAMPA / kainate antagonist. 1 ml water soluble pack.
Water soluble, potent, selective and competitive AMPA/kainate receptor antagonist. Neuroprotective and anticonvulsant in vivo.
Soluble in 1 ml water to give specified mM/ml concentration. Find out more.
Chemical name2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in 1 ml water to give specified mM/ml concentration
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144489 has been referenced in 7 publications.
- Perez-Rosello T et al. Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis. J Neurosci 33:9259-72 (2013). PubMed: 23719795
- Narboux-Nême N et al. Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex. J Neurosci 32:6183-96 (2012). PubMed: 22553025
- Zhang W & Linden DJ Calcium influx measured at single presynaptic boutons of cerebellar granule cell ascending axons and parallel fibers. Cerebellum 11:121-31 (2012). PubMed: 20049574
- Palucha-Poniewiera A et al. On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039. Psychopharmacology (Berl) 212:523-35 (2010). PubMed: 20703449
- Atlason PT et al. Mapping the ligand binding sites of kainate receptors: molecular determinants of subunit-selective binding of the antagonist [3H]UBP310. Mol Pharmacol 78:1036-45 (2010). PubMed: 20837679
- Evrard A & Ropert N Early development of the thalamic inhibitory feedback loop in the primary somatosensory system of the newborn mice. J Neurosci 29:9930-40 (2009). PubMed: 19657043
- Zhang W & Linden DJ Neuromodulation at single presynaptic boutons of cerebellar parallel fibers is determined by bouton size and basal action potential-evoked Ca transient amplitude. J Neurosci 29:15586-94 (2009). PubMed: 20007482