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  1. Link

    nch-51-hdac-inhibitor-ab120949.pdf

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Biochemicals Pharmacology Signaling Epigenetics Histone Deacetylases (HDAC)
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NCH 51, HDAC inhibitor (ab120949)

  • Datasheet
  • SDS
  • COA
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  • Datasheet
  • References

Overview

  • Product name

    NCH 51, HDAC inhibitor
  • Description

    Novel HDAC inhibitor
  • Alternative names

    • PTACH
  • Biological description

    Novel HDAC inhibitor (IC50 values are 32, 48 and 41 nM at HDAC4, HDAC1 and HDAC6, respectively). Induces apoptosis and inhibits cell growth of various malignant cells and tumor cells lines (EC50 = 3.8 μM). Also reactivates latent HIV-1 gene expression.
  • Purity

    > 99%
  • CAS Number

    848354-66-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Methylpropanethioic acid S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester
  • Molecular weight

    390.56
  • Molecular formula

    C20H26N2O2S2
  • PubChem identifier

    11395181
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(Nc1nc(cs1)c2ccccc2)CCCCCCSC(=O)C(C)C
  • Source

    Synthetic

  • Research areas

    • Biochemicals
    • Pharmacology
    • Signaling
    • Epigenetics
    • Histone Deacetylases (HDAC)
    • Biochemicals
    • Research Area
    • Cancer
    • Epigenetics
    • Histone Deacetylases (HDAC)
    • Biochemicals
    • Research Area
    • Epigenetics
    • Histone Deacetylases (HDAC)

Datasheets and documents

    • Datasheet
    • SDS
    • COA
  • References

    This product has been referenced in:

    • Victoriano AF  et al. Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression. FEBS Lett 585:1103-11 (2011). Read more (PubMed: 21402072) »
    • Sanda T  et al. Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells. Leukemia 21:2344-53 (2007). Read more (PubMed: 17690692) »
    • Suzuki T  et al. Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J Med Chem 48:1019-32 (2005). Read more (PubMed: 15715470) »

    Publishing research using ab120949? Please let us know so that we can cite the reference in this datasheet.

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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